Menopause May Reshape the Brain: New Study Reveals Grey Matter Loss
A major new study connects menopause to changes in brain structure. University of Cambridge researchers found grey matter loss in areas linked to memory and emotion. In addition, many women reported higher anxiety, depression, and fatigue. This research suggests menopause is a key transition for brain health. However, hormone therapy did not reverse these brain changes. It may, however, slow some age-related declines
Understanding Menopause Symptom
Menopause occurs when menstrual periods stop, usually between ages 45 and 55. This natural transition often brings hot flashes, mood changes, and sleep issues. Prior research also links it to shifts in memory and attention. Many women use hormone replacement therapy (HRT) to manage symptoms. Despite its use, scientists still know little about how menopause and HRT affect the brain long-term.
Key Findings on Mental Health and Cognition
The study analyzed data from nearly 125,000 UK women. Post-menopausal women sought more help for anxiety and depression. They also reported more insomnia and tiredness. Cognitive tests showed slower reaction times after menopause. Importantly, memory remained stable. HRT users, however, showed slightly slower reaction time declines.
Brain Scans Reveal Grey Matter LossBrain imaging revealed significant grey matter loss in post-menopausal women. This loss occurred whether they used HRT or not. Affected areas included the hippocampus and anterior cingulate cortex. These regions handle memory and emotional regulation. They are also vulnerable to Alzheimer’s disease. This link may help explain why more women than men develop dementia.
