A new study from the German Center for Diabetes Research (DZD) has uncovered compelling evidence that sugary soft drinks may influence not only physical health but also mental well-being, particularly in women. While these beverages are long associated with obesity, diabetes, and heart disease, researchers now suggest that their effects on the gut microbiome could also contribute to depression.
The findings are based on data from the Marburg-Münster Affective Cohort Study (MACS), which analyzed 932 adults aged 18 to 65 between 2014 and 2018. Among the participants, 405 were diagnosed with major depressive disorder (MDD) and 527 served as healthy controls. Results showed that individuals who consumed more soft drinks had a higher likelihood of both being diagnosed with depression and experiencing more severe symptoms. This association was strongest among women, where frequent consumption was linked to a 17% increased risk of depression.
Researchers believe the explanation lies within the intestinal microbiome. Women who regularly consumed sugary drinks displayed higher levels of Eggerthella bacteria, which earlier studies had already connected with depressive disorders. The study is the first to provide strong evidence that this bacterium may act as a mediator between sugary drink intake and depressive symptoms. Interestingly, this pattern was not observed in men, suggesting possible hormonal or immune-related differences between the sexes.
The implications of these findings are far-reaching. Experts emphasize that nutrition plays a vital role in shaping mental health and that microbiome-based interventions—such as dietary adjustments or probiotics—may offer new strategies for preventing and treating depression. As DZD researcher Rachel Lippert explained, even small changes in consumer habits could have significant benefits, particularly given the widespread global consumption of soft drinks. The study highlights the importance of integrating dietary education into mental health care and prevention programs.
Sugary Soft Drinks Linked to Higher Depression Risk in Women, Study Finds
