Protein That Reverses Brain Aging Found in Singapore
Singapore scientists found a protein that reboots aging brains. It restores stem cells lost during aging. This could lead to treatments for memory loss. The protein is DMTF1. It controls gene activity. Aging brains have low DMTF1 levels. Stem cells then stop renewing. Memory and learning suffer as a result. Researchers boosted DMTF1 in aged cells. The cells began regenerating again. Therefore, the protein may reverse age-related damage.
Who Conducted the Study?
The team worked at NUS Medicine. Assistant Professor Ong Sek Tong Derrick led the research. Dr. Liang Yajing was the first author. They published in Science Advances. They studied human cells and lab models. Both showed similar aging patterns.DMTF1 activates two helper genes. These genes loosen tightly packed DNA. Growth genes then switch on. Stem cells multiply and form neurons. Neurons support memory and learning. Without them, cognitive decline sets in.
Why Is This Important?
Brain aging affects millions worldwide. Current treatments only manage symptoms. This discovery targets the root cause. However, the research is still early. The team plans animal studies next. They must also rule out tumor risks. Scientists will test DMTF1 in living models. They want to see if memory improves. They also seek safe molecules that boost DMTF1 naturally. “Our work is in its infancy,” Dr. Liang said. “But it gives us a clear path forward.”
