Antidepressant Side Effects Ranked: Study Reveals Big Differences Between Drugs
Side effects of antidepressants have been ranked for the first time, revealing major differences between common medications. Researchers found that some drugs can change a patient’s weight or heart rate within just eight weeks of treatment. However, experts stress that no one should stop their medication without consulting a doctor.
The study, published in The Lancet Medical Journal, analyzed 151 studies covering 30 antidepressants and more than 58,500 patients. It was led by King’s College London and the University of Oxford. The findings highlight how each drug can affect the body differently.
Major Differences Between Drugs
According to the research, some antidepressants caused weight gain of up to 2 kilograms, while others led to weight loss. For example, agomelatine users lost an average of 2.4kg, whereas maprotiline users gained nearly 2kg. Heart rate also varied by as much as 21 beats per minute between fluvoxamine, which slowed it down, and nortriptyline, which increased it.
These variations matter. Professor Oliver Howes from King’s College London said that even small physical changes can have a large effect across the population. In addition, differences in blood pressure were also noted, with an 11 mmHg gap between nortriptyline and doxepin.
Personalized Treatment Matters
Dr. Atheeshaan Arumuham explained that no two antidepressants are the same. Therefore, matching medication to a person’s health profile is essential. For instance, someone concerned about weight gain might prefer agomelatine or sertraline. On the other hand, patients with high blood pressure may need a different option.
Dr. Toby Pillinger emphasized that the findings are meant to empower patients. He encouraged people to discuss their treatment choices with healthcare professionals and make informed decisions together.
