Great Unified Microscope Reveals Hidden Micro and Nano Worlds
Researchers at the University of Tokyo have introduced a groundbreaking microscope that captures forward- and back-scattered light at the same time. This combined view lets scientists observe large cell structures and tiny nanoscale particles in a single image. As a result, it opens the door to clearer and more detailed imaging than ever before.The new system works without dyes or stains. Therefore, it stays gentle on living cells and supports long-term studies. In addition, this approach makes it useful for testing and quality control in pharmaceutical and biotech labs.
Why This Innovation Matters
Modern microscopes often force researchers to choose between sensitivity and scale. For example, quantitative phase microscopy highlights larger cellular shapes. However, it struggles to capture extremely small features. Interferometric scattering microscopy detects nanoscale particles, but it loses the broader view of the entire cell.The new “Great Unified Microscope” removes this trade-off. It merges both directions of scattered light, offering a complete picture of structures across different sizes. As a result, scientists can watch fast changes inside cells while still seeing the bigger cellular landscape.
How the Team Achieved Dual Detection
The researchers captured a single image carrying both forward- and backward-scattered signals. They then separated these signals with high precision. This allowed them to track the movement of both large and very small particles inside cells. They also estimated the size and refractive index of each particle, giving deeper insight into how light interacts with different cell components.
What Comes Next
The team now plans to study even smaller particles, such as exosomes and viruses. They hope this method will reveal how cells move toward death and how these tiny particles behave in different environments.
